Simulation on the internal structure of three-dimensional proximal tibia under different mechanical environments
نویسندگان
چکیده
BACKGROUND Bone can adjust its morphological structure to adapt to the changes of mechanical environment, i.e. the bone structure change is related to mechanical loading. This implies that osteoarthritis may be closely associated with knee joint deformity. The purposes of this paper were to simulate the internal bone mineral density (BMD) change in three-dimensional (3D) proximal tibia under different mechanical environments, as well as to explore the relationship between mechanical environment and bone morphological abnormity. METHODS The right proximal tibia was scanned with CT to reconstruct a 3D proximal tibia model in MIMICS, then it was imported to finite element software ANSYS to establish 3D finite element model. The internal structure of 3D proximal tibia of young normal people was simulated using quantitative bone remodeling theory in combination with finite element method, then based on the changing pattern of joint contact force on the tibial plateau in valgus knees, the mechanical loading was changed, and the simulated normal tibia structure was used as initial structure to simulate the internal structure of 3D proximal tibia for old people with 6° valgus deformity. Four regions of interest (ROIs) were selected in the proximal tibia to quantitatively analyze BMD and compare with the clinical measurements. RESULTS The simulation results showed that the BMD distribution in 3D proximal tibia was consistent with clinical measurements in normal knees and that in valgus knees was consistent with the measurement of patients with osteoarthritis in clinics. CONCLUSIONS It is shown that the change of mechanical environment is the main cause for the change of subchondral bone structure, and being under abnormal mechanical environment for a long time may lead to osteoarthritis. Besides, the simulation method adopted in this paper can more accurately simulate the internal structure of 3D proximal tibia under different mechanical environments. It helps to better understand the mechanism of osteoarthritis and provides theoretical basis and computational method for the prevention and treatment of osteoarthritis. It can also serve as basis for further study on periprosthetic BMD changes after total knee arthroplasty, and provide a theoretical basis for optimization design of prosthesis.
منابع مشابه
The use of combined 3.5 LCP unicortical plate and nail fixation in proximal tibia fractures and prevention of valgus and anterior angulation
Introduction: Intramedullary nailing (IMN) of high tibia fracture has some mechanical and biological advantages over the other form of fixation. However, valgus, apex anterior malalignment and anterior displacement of proximal fragment commonly occur after isolated IMN fixation of proximal high tibia fracture. The purpose of this study is to determine the effectiveness of using 3.5-mm locking c...
متن کاملEvaluation of bone deformities of the femur, tibia, and patella in Toy Poodles with medial patellar luxation using computed tomography.
OBJECTIVES To evaluate morphological parameters of the femur, tibia, and patella in Toy Poodles with medial patellar luxation (MPL) using three-dimensional (3D) computed tomography (CT) and to compare these parameters between radiography and CT. METHODS Thirty-five hindlimbs of Toy Poodles were divided into normal and grade 2 and 4 MPL groups. The anatomical and mechanical lateral proximal fe...
متن کاملAnalytical Solution for Electro-mechanical Behavior of Piezoelectric Rotating Shaft Reinforced by BNNTs Under Non-axisymmetric Internal Pressure
In this study, two-dimensional electro-mechanical analysis of a composite rotating shaft subjected to non-axisymmetric internal pressure and applied voltage is investigated where hollow piezoelectric shaft reinforced by boron nitride nanotubes (BNNTs). Composite structure is modeled based on piezoelectric fiber reinforced composite (PFRC) theory and a representative volume element has been cons...
متن کاملOne Dimensional Internal Ballistics Simulation of Solid Rocket Motor
An internal ballistics model has been developed for performance prediction of a solid propellant rocket motor. In this model a 1-D unsteady Euler equation with source terms is considered. The flow is assumed as a non-reacting mixture of perfect gases with space and time varying thermo physical properties. The governing equations in the combustion chamber are solved numerically by using the Steg...
متن کاملNumerical Study of Bubble Separation and Motion Using Lattice Boltzmann Method
In present paper acombination of three-dimensional isothermal and two-dimensional non-isothermal Lattice Boltzmann Method have been used to simulate the motion of bubble and effect of wetting properties of the surface on bubble separation. By combining these models, three-dimensional model has been used in two-dimension for decreasing the computational cost. Firstly, it has been ensured that th...
متن کامل